The instruction "Apply to clean, dry skin AM + PM" indicates that you should use the product in your skincare routine both in the morning (AM) and evening (PM). It's important to apply the product to skin that has been cleansed and is dry.If you have questions or need guidance on the recommended order to apply your ZO® skincare products, it's advisable to contact your local physician or speak to a ZO® Skincare Specialist through their live chat. They can provide you with personalized recommendations based on your specific skincare needs and the ZO® products you are using. Following a proper skincare routine and product application order can help you achieve the best results for your skin.